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Polyglutamic Acid

Polyglutamic Acid and Its Benefits on Skin

Have you heard of polyglutamic acid (PGA), one of the cutting-edge technologies in skincare?!? PGA has stirred up an internet frenzy because of its ability to absorb up to 5,000 times its own weight in water! That means it is an EXTREMELY powerful humectant which can deliver keep the skin hydrated and reduce the appearance of wrinkles. This breakout natural ingredient in skincare is non-toxic, biodegradable, water-soluble, even edible! Here is everything you need to know about this Hero ingredient!

The science of polyglutamic acid

Polyglutamic Acid is a protein comprised of the amino acid Glutamic Acid. It is found naturally via fermentation of soybeans. Polyglutamic acid exists in two forms – alpha polyglutamic acid (synthesized chemically) or gamma polyglutamic acid (synthesized by the fermentation process). More skin research has been done on the natural gamma polyglutamic acid, which is what we will discuss.

The benefits of Polyglutamic acid

Research has shown that the benefits of polyglutamic acid are numerous (Ben-Zur & Goldman, 2014). Polyglutamic acid stimulates our skin to produce natural moisturizing factors, which are molecules that attract and bind water to our skin. In addition, polyglutamic acid protects our skin from losing moisture by strengthening its skin barrier function, thereby increasing the ability of our skin to retain moisture. 

Skin hydration is plays a role in prevent skin aging by increasing skin elasticity and promoting healthy skin. Research shows that polyglutamic acid increases skin elasticity as early as 2 weeks after use! Incorporating polyglutamic acid into your skincare routine will help tremendously replenish the moisture in our skin, leaving our skin smooth, firm, and with reduced appearance of wrinkles. Polyglutamic Acid is known to be effective at concentrations as low as 0.1%!

Polyglutamic acid and Hyaluronic acid

Hyaluronic acid and Polyglutamic acid should be new best friends! Hyaluronic acid occurs naturally in our bodies, but its concentration in our skin decreases over time, leading to sagging and wrinkled skin. Polyglutamic acid inhibits the hyaluronidase enzyme which normally breaks down HA. In it's hydrogel form, the larger polyglutamic acid molecules form a soft and smooth film outside of your skin, whereas the smaller hyaluronic acid molecules penetrate and hydrate your skin. This means that when combined, PGA and HA can prevent your skin from losing its natural moisture (PGA) and also restore any moisture already lost (HA)! The synergistic effects of these two powerhouse humectants is a great way to refresh and energize your skin.

Hale Cosmeceuticals Inc- Your Skin Health Company

At Hale Cosmeceuticals all of our products are based on SCIENCE and aimed to deliver RESULTS!! We have been used and recommended by Skincare professionals like Estheticians and Dermatologists for over 30 years! We have products which can be used by persons of ALL ages and ALL skin types!! Check out our website for information about Vitamin C, Peptides, Retinol, and more!!!

1. Ben-Zur, N., & Goldman, D. M. (2014). Polyglutamic Acid: A Novel Peptide for Skin Care. Cosmetics Toiletries, 122, 65–74.
2. Choi, H. J., & Kunioka, M. (1995). Preparation conditions and swelling equilibria of hydrogel prepared by γ-irradiation from microbial poly(γ-glutamic acid). Radiation Physics and Chemistry, 46(2), 175–179.
3. Choi, H. J., Yang, R., & Kunioka, M. (1995). Synthesis and characterization of pH-sensitive and biodegradable hydrogels prepared by γ irradiation using microbial poly(γ-glutamic acid) and poly(ε-lysine). Journal of Applied Polymer Science, 58(4), 807–814.
4. Hasabe, K., & Inagaki, M. (1998). Preparation composition for external use containing gamma-polyglutamic acid and vegetable extract in combination (Patent No. JPH11240827A).
5. Ho, G.H., Yang, J., & Yang, T.H. (2005). Gamma polyglutamic acid (gamma-pga, h form), gamma-polyglutamate hydrogels for use as super moisturizers in cosmetic and personal care products (Patent No. EP1690525A1).
6. Kunioka M. (1993). Polymers and Environment I. Properties of Hydrogels Prepared by Gamma-Irradiation in Microbial Poly(gamma-glutamic acid) Aqueous Solutions. KOBUNSHI RONBUNSHU, 50(10), 755–760. 
7. Ogunleye, A., Bhat, A., Irorere, V. U., Hill, D., Williams, C., & Radecka, I. (2015). Poly-γ-glutamic acid: Production, properties and applications. Microbiology (Reading, England), 161(Pt 1), 1–17. 
8. Sung, M. H., Park, C., Choi, J. C., Uyama, H., & Park, S. L. (2005). Hyaluronidase Inhibitor Containing Poly-Gamma-Glutamic Acid as an Effective Component (Patent No. US20080247986A1).


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